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Vaccines

Vaccines are biologically active products designed to stimulate the immune system against future invasion of a pathogen by inducing memory to specific antigens. Vaccines may be produced from viral pathogens such as those causing polio, influenza and Lyme Disease, or from bacterial pathogens such as pertussis, tetanus, diphtheria and anthrax. Recombinant fermentation techniques such as those used for hepatitis vaccine, produce highly purified antigen-specific subunits that stimulate immunity without concern of pathogen infection. Vaccine production typically uses several filtration and purification steps. To obtain a purified vaccine the selected microorganism must first be grown then the selected antigen must be separated, purified, formulated and sterilized prior to delivery.

Understanding the Options
Application Requirements
  • Vaccine broths have moderate to high solids concentrations that require effective removal before downstream purification. Millipore products are designed for high yield, throughput and efficiency.
  • Highly purified vaccines are often required to minimize adverse reaction.
  • Injectable vaccines require sterilization.

VaccinesBatch Volumes
Mammalian Cell<2,000 L
Viral Vectors<500 L
Plasmid DNA<5,000 L
Conjugates <1,000 L
Polysaccharides <2,000 L